Showing posts with label skin care. Show all posts
Showing posts with label skin care. Show all posts

Thursday, 1 March 2018

Purified vs Distilled vs Regular Water: What’s the Difference?

Optimal water intake is essential for your health.
Every cell in your body needs water to function correctly, which is why you must continuously hydrate throughout the day.
Most people know how important water intake is, but some are confused over the best type of water to drink.
This article investigates the differences between purified, distilled and regular water to find out which one is the best choice for hydration.
Purified water is water that has been filtered or processed to remove impurities like chemicals and other contaminants.
It is usually produced using groundwater or tap water.
Through purification, many types of impurities are removed, including:
·        Bacteria
·        Algae
·        Fungi
·        Parasites
·        Metals like copper and lead
·        Chemical pollutants
Several methods are used to purify water commercially and in the home.
In most Western countries, public drinking water is purified to make water safe for human consumption.
However, standards for drinking water around the world vary and are typically based on governmental regulations or international standards.
In fact, the World Health Organization estimates that over 2.1 billion people lack access to safe drinking water.
In countries that purify public drinking water, various treatment methods are used to make water safe, including:
·        Coagulation and flocculation: Positively charged chemicals are added to water to bind with negatively charged particles so they can be filtered out. This forms larger particles called floc.
·        Sedimentation: Due to its larger size, floc settles to the bottom of the water supply, separated from the clean water.
·        Filtration: The fresh water on top of the amount then flows through numerous filtration systems made of sand, charcoal, and gravel. This removes contaminants like dust, bacteria, chemicals, and viruses.
·        Disinfection: During this step, chemical disinfectants like chlorine are added to the water to kill any remaining bacteria or viruses that may have survived the first few steps.
It’s important to note that water may be treated differently depending on the area and quality of the local water.
SUMMARY: Purified water is water that has been processed to remove contaminants like dirt and chemicals. In many countries, tap water is purified to make it safe for human consumption.
While tap water is safe to drink in many areas, it may still contain trace contaminants.
For example, the US Environmental Protection Agency (EPA) sets legal limits that are considered safe for consumers for over 90 contaminants in drinking water.
However, the Safe Water Drinking Act gives individual states the ability to regulate their own drinking water standards, as long as they meet the EPA’s minimum requirements for contaminants.
This means that some states have more stringent drinking water regulations than others.
Although measures are taken to ensure that public drinking water is safe for consumption, it can contain trace amounts of contaminants that could negatively impact health.
For instance, the heavy metals lead, and copper are incredibly toxic to health. They can cause stomach distress and lead to brain damage when ingested over time.
These heavy metals have been known to leach into drinking water, even in countries where public water sources are carefully regulated.
By using in-home water filters or drinking purified bottled water, drinking water undergoes another level of purification that can remove metals, chemicals, and other contaminants, depending on the type of purification system used.
Water purification systems like charcoal filters remove chlorine, a common chemical added to the public water supply as a disinfectant.
Several studies have linked chlorinated water to an increased risk of certain cancers, including colorectal cancer.
Another benefit of water purification is that it removes unpleasant tastes associated with chemical treatments, organic matter or metal plumbing, leaving you with fresh, pure-tasting drinking water.
SUMMARY: Water purification removes contaminants that may remain in drinking water and improves water quality and taste.
While purified water has many health benefits, it also has some potential drawbacks.
For example, fluoride is a mineral that is added to public drinking water supplies in some countries to improve dental health and reduce dental decay.
Although this practice has led to decreased tooth decay in children, especially in at-risk areas, some argue that fluoridated water is not worth the potential health risks associated with its use.
Excessive fluoride levels can be toxic to both brain and nerve cells, and long-term exposure to high levels of fluoride has been linked to learning, memory and cognitive deficits.
However, experts argue that the level of fluoride found in drinking water is safe and beneficial in reducing tooth decay, especially in children who are only exposed to fluoride through drinking water.
Research on the safety and efficacy of fluoridated water is ongoing, but those who drink purified water should be aware that some purification systems remove fluoride from drinking water.
Some other disadvantages of purified water include:
·        Upkeep: Water purification systems must regularly be maintained. If not properly managed, contaminants can build up in old filters and leach into your drinking water.
·        May does not remove some pollutants: Although water purification systems remove many contaminants, certain pesticides and chemicals may remain in purified water depending on the type of purification used.
·        Cost: Both installing an in-home water purification system and buying purified bottled water can be expensive, with some systems costing hundreds of dollars.
·        Waste: Buying purified water in plastic bottles leads to a significant amount of waste, as does dispose of used filters from in-home purification systems.
SUMMARY: Water purification may not remove all contaminants from drinking water, and specific purification systems can be costly and involve upkeep. Specific purification methods remove fluoride, a mineral added to drinking water to improve dental health.
Distilled water has gone through the process of distillation to remove impurities.
Distillation involves boiling water and collecting the steam, which returns to pool upon cooling.
This process is very effective at removing contaminants like bacteria, viruses, protozoa like giardia and chemicals like lead and sulfate.
Due to the fact that distilled water is exceptionally pure, it is commonly used in medical facilities and laboratories.
Though drinking distilled water is not as ordinary as drinking other types of purified water, some people choose to drink it because it is free of contaminants.
Benefits of Distilled Water
Water distillation is an efficient way to remove contaminants from drinking water.
Levels of pesticides and other chemicals in public water sources like tap water will depend on your geographic location and the agencies that regulate drinking water safety in your country.
Distilled water is substantially free of contaminants like pesticides and bacteria, which could be especially helpful to those with weakened immune systems.
For example, those with HIV/AIDS and certain cancers are at an increased risk of becoming sick from impurities in food and water and may benefit from drinking distilled water.
What’s more, like some other purification methods, distilled water effectively removes chlorine from drinking water, which can improve the taste of water while decreasing your exposure to chlorine.
Potential Risks of Distilled Water
While distilled water is the purest type of water, it’s not necessarily healthiest.
The distillation process is very effective at removing potentially harmful contaminants, but it also removes the natural minerals and electrolytes found in water.
Along with unwanted impurities, beneficial minerals like calcium and magnesium are also left behind as the steam rises during the distillation process.
In fact, distillation typically removes around 99.9% of all minerals found in tap water.
Though water is not usually thought of as a source of minerals, any factor that leads to a decreased intake of essential micronutrients could negatively impact your health.
For example, drinking water that's low in calcium and magnesium has been associated with an increased risk of fracture, preterm birth, and heart disease).
However, it’s important to note that tap water is not a significant source of mineral intake for most people, and drinking distilled water should be relatively safe as long as a well-balanced diet is followed.
Like other methods of purification, distillation removes fluoride from drinking water, which may put those who choose to drink distilled water at an increased risk of cavities.
This makes it essential for those who drink distilled water to maintain proper dental hygiene.
SUMMARY: Distilled water is a type of purified water that is virtually free from contaminants. The distillation process removes fluoride and natural minerals found in drinking water.
In most cases, public drinking water sources like tap water are safe due to the strict contaminant limits set by regulatory agencies.
However, drinking water can become contaminated from natural sources or human activity, affecting water quality.
For this reason, it may be a good idea to invest in an in-home water purification system, especially those who are immunocompromised and more susceptible to becoming ill from contaminated water.
In countries where water contamination is an issue, especially in developing countries with lack of proper sanitation, choosing bottled or purified water is always the safest option.
Many types of purification systems are available, including charcoal and UV filters, which remove impurities that may survive the initial, large-scale purification process that most tap water goes through.
That being said, in countries where public drinking water is regulated for quality and safety, drinking tap water is relatively safe.
If you question the quality of your tap water, you can test the water by purchasing a home test kit or contacting a water testing agency in your area.
SUMMARY: Though consuming tap water is safe in countries where drinking water is regulated, water purification may be necessary for areas where water contamination is an issue.
Most public sources of drinking water are regulated for safety, but some people choose to use home water purifiers to further improve water quality.
Household water treatment units can improve the taste or odor of tap water and remove specific contaminants.
Point-of-use (POU) treatment systems purify only the water that is used for consumption (drinking and cooking). Point-of-entry (PUE) treatment systems typically treat all of the water entering a home.
POU systems are less expensive and therefore more commonly used in households.
These filtration systems attach to the faucet or sit under the sink and also come in free-standing water pitchers with built-in filters like the popular Brita water filter.
Some refrigerators also come with built-in water purification systems.
Most in-home water filtration systems use the following purification techniques:
·        Filtration: Filtration systems trap unwanted impurities in the surface or pores of an absorbent medium. Charcoal filters fall into this category.
·        Reverse osmosis: These systems use a semipermeable membrane that removes impurities.
·        UV light: UV light filtration systems use ultraviolet light to disinfect water by killing potentially harmful bacteria and viruses.
Depending on the type and model, prices can range from $20 to hundreds of dollars.
No matter what type of filter you choose, be sure to look for brands with certifications from regulatory agencies like the American National Standards Institute (ANSI) and NSF International.
These agencies certify that home water purification systems meet or exceed national drinking water standards.
Home water purification systems must be adequately maintained. As a result, it’s essential to follow the manufacturer's recommendations for upkeep, including filter replacement, to ensure that your water is being adequately purified.
SUMMARY: There are many ways to purify your drinking water, including charcoal filters, UV light filtration systems and reverse osmosis systems.
Access to clean drinking water is vital to health.
While most sources of public drinking water are strictly regulated and safe to drink, many prefer to drink purified water.
Purified water is relatively safe and may reduce exposure to specific contaminants that can be found in tap water.
Remember that water quality can vary depending on where you live. This should be the determining factor when choosing to drink purified water or tap water.
Just to let you know:

L&G is a small family business, and we always come from personal experience.
 
For those who may want to support different health conditions can fully trust our 100% Natural Proven Healthy Nutritional Supplement products. Check the links below:


=> Cholesterol and Heart Health - http://tiny.cc/MyOmega
=> Inflammation - http://tiny.cc/YourTurmeric
=> Metabolism Boost and Weight Control - http://tiny.cc/YourForskolin
=> Gut Flora, or Upset Stomach - http://tiny.cc/BetterStomach
=> Anxiety and Stress Support - http://tiny.cc/BeYou


L&G - "Life and Greatness Nutrition" 15 years of experience!!!



source : Water  

Thursday, 9 November 2017

The 10 Most Annoying Women's Health Issues and How to Fix Them


 

Ladies, you know about your significant health issues -- breast cancer, osteoporosis, heart disease -- but what about the smaller, everyday health problems? You know, the ones that are relatively common but don't cause doing concern. Between juggling your job, family commitments, social life and any of the other thousand things on your plate, it seems like an unnecessary chore to try to get in to see your doctor for something that’s minor. So what’s a busy woman to do about a problem that’s only mildly annoying? If you’re plagued by any of these 10 common health issues, consider giving these expert-recommended fast fixes a shot.



1 PMS
If you find yourself getting particularly weepy (well, more crying than normal) during those ASPCA animal shelter commercials at a particular time of the month, blame it on good ol’ PMS. According to the American College of Obstetricians and Gynecologists (as reported by womenshealth.gov in 2014), it’s estimated that 85 percent of menstruating women have at least one PMS symptom as part of their monthly cycle. These symptoms can include acne, tender breasts, bloating or upset stomach, headaches, food cravings, mood swings, anxiety, depression, trouble sleeping or tiredness. Yeah, being a woman is a real treat. But there are a few “quick fixes” you can do to lessen these symptoms. According to Alison M. Leong, M.D., “To combat PMS naturally, try decreasing your sugar, salt, caffeine and alcohol intake.” Holding off on these can also help cramps if you additionally suffer from those. “Increase your exercise, calcium and vitamin B to help boost your mood and reduce PMS symptoms like depression and anxiety,” she says.


2 MENSTRUAL CRAMPS
Whether you call it “a visit from Aunt Flo” or “Shark Week,” getting your period is no picnic, and menstrual cramps are one of the most common health issues that women face. To calm cramps quickly, opt for an anti-inflammatory that reduces muscle pain. Alison M. Leong, M.D., says, “Try over-the-counter pain relievers like Motrin, Aleve or Midol.” It sounds simple, but she insists these can be quite effective. Couple some OTC painkillers with a heating pad or hot-water bottle on the areas that are the most painful. After all, cramps are caused by contracting muscles in your uterus, so treating PMS cramps like you would sore muscles from a workout makes sense. If you prefer a more natural approach, Susan Lark, M.D., author of “Dr. Susan’s Solutions says: “Sit on a comfortable carpet or pillow with the soles of your bare feet touching each other, then use your thumbs to firmly massage your arches for at least three minutes.” She explains - “This acupressure technique helps stimulate the release of endorphins, which are powerful painkilling hormones.” Note that if you regularly experience crippling pain, you should see your doctor or gynecologist to rule out conditions like endometriosis or fibroids.


3 COLD SORES
Ah, the evil cold sore! One minute, you’re rocking your favorite red lipstick for a happy hour or a hot date. The next, you discover that you’ve got a pus-filled blister living on your lip. Is it too late to cancel? While cold sores can pop up out of nowhere, they’re caused by the herpes simplex virus. According to research, about 90 percent of people get at least one cold sore in their life. If you’re no stranger to cold sores and usually get one due to physical or mental stress or the hormone imbalance that can be caused by your period, you don’t have to go into hibernation just yet. Healthcare professional Dr. Jenny Tylee suggests this home remedy on Disabled World: “To heal a cold sore fast, try taking 1,000 milligrams to 3,000 milligrams of lysine in capsule supplements during an outbreak. Or you can eat high-lysine foods like meats and dairy products. And applying ice as soon as you feel that first tingle or itch will greatly reduce or delay the cold sore.” 
Standardized Turmeric Root powder is also an effective antiinflammation supplement which knocks down everyday environmental pollutants causing aging and body inflammation.

Get Best Daily Turmeric Capsules HERE ==>> Turmeric Curcumin C3 Complex® 

4 VAGINAL ITCHING
Ah, your delicate lady-flower. On a typical day, it’s an entirely balanced ecosystem of microorganisms. But at times stress, hormones, antibiotics, soaps or other influences can upset the equilibrium and cause a characteristic female problem that’s downright unbearable. Instead of discreetly rubbing your privates in a desperate attempt to scratch that itch away, Dr. Leong suggests this quick fix: “Just run into your nearby drugstore and pick up Monistat or Vagisil.” She adds, “You can also try a vinegar-and-water douche, or you can make your own using two tablespoons of apple cider vinegar and a cup of warm filtered water.” However, if the itching continues, it could be a sign of something more serious, so you should make an appointment with your doctor.


5 WATER RETENTION
Birth-control pills. Hormone imbalances. High blood pressure. Pregnancy. All of these things can cause women to retain water and feel kind of puffy. Unfortunately, many women experience the evils of water retention with no relief other than layering on some Spanx to suck in all the liquid girth. However, there are a couple of fast, simple ways you can prevent or reduce your body’s urge to hold on to excess fluid. “One of the quickest, easiest things you can do,” says Alison M. Leong, M.D., “is drinking a diuretic tea, such as green tea or dandelion leaf tea.” She adds, “If you’re prone to water retention around the time of your period, be sure to watch your salt cravings.”

For everyday detox cleanse ==>> Ultra Flora Probiotic 40 Billion Supplement



6 STOMACHES AND CONSTIPATION
When you’re stressed out, worried or anxious, does it feel like there’s a thick rope of knots in your stomach? If so, you’re not alone. Gastroenterologist and founder of the Digestive Centre for Women in Washington, D.C., Dr. Robynne Chutkan explains to the Daily Mail that women have a longer colon than men, which makes them more apt to have intestinal problems like stomachaches, constipation and bloating. She tells Health magazine that stress is a common cause of stomachaches and suggests this acupressure trick to release feel-good endorphins and help you relax: “For five minutes gently apply pressure in a circular motion with your fingers to the area that’s four finger-widths above your navel.” Also, she says that a fast 10-minute walk can help get things moving.

for bloating and constipation ==>> Daily Probiotic


7 PAINFUL INTERCOURSE
Women dig doin’ it. But there are times when it’s less “yes, yes, oh God, YES!” and more “OUCH!” This can put a damper on your sex life. If you’re a woman who’s experiencing painful intercourse and you don’t have endometriosis (a condition in which the tissue that lines the uterus starts growing in other areas), Alison M. Leong, M.D., says that maybe your issue is simply a lack of lubrication. Her fast fix? Hit up the lube aisle at your local drugstore. Leong says, “You can use K-Y Jelly or other water-soluble lubricants and see if that makes things feel less painful and more pleasurable.” One small bottle of lube could be the magical game changer you need.


8 BLISTERS
Rocking a new pair of heels can make you feel like a vixen on wheels. But when it comes to breaking them in, it can be a struggle just to make it to lunchtime without limping like a wounded deer. According to experts at Reader’s Digest, putting a bandage on a heel can rub as you go, making the pain feel worse. Instead, they suggest, “Put a gauze square over the actual sore, then cover your heel with a wide strip of duct tape and you’ll be back on the road.”


9 INSOMNIA
There’s nothing better than getting a restful night’s sleep, but, sadly, according to a National Sleep Foundation’s Sleep in America poll of all adults, this is a distant dream for many women. In fact, women are more likely than men to have difficulty falling and staying asleep. So besides downing ZzzQuil in the middle of the night and risking feeling groggy in the morning, what’s a sleepy lady to do in a pinch? Well, often, we lie awake because we can’t shut off our brains. If this is the case, psychologist Dr. Ellen Hendriksen writes in QuickandDirtyTips.com, “If you can’t stop thinking about your to-do list, write it out. Or get up and do something nonstimulating, such as filling out a crossword or reading a book (the paper kind). Avoid your laptop, tablet or smartphone. The blue light emitted from the screen suppresses melatonin, the hormone that helps sleep.”
For Deep Sleep support and Anxiety Relief ==>> Cordy Max Supplement

10 SCARS
You’ve probably heard inspirational quotes about how you should be proud of your scars. That’s fine and all -- unless you want to hide them because the less-than-noble story behind them involves a steak knife or your fickle cat. If you’re dead set on helping your scar heal, heed this quick fix from Prevention magazine: “Contrary to popular belief, scabbing is not ideal. Instead, keep it moist with petroleum jelly and a bandage for three to five days. Overnight, put cellophane tape over the jelly. The tape keeps water trapped in the skin better than breathable bandages, encouraging healthy collagen growth.”



Thursday, 19 October 2017

Why Sugar is Responsible for Aging Skin



Have you been noticing a few extra wrinkles, some deep lines or sagging in your skin? Sugar may be one of the culprits. Yes, sugar gives us that momentary rush of heaven, that temporary hit to our taste buds and who can resist that decadent dessert presented so beautifully, yet all the while feeling a twinge of guilt with that potential of more jiggle in our midst.



 …But whose worrying that the decadent dessert will cause wrinkles and even sagging skin. Not many.

Sugar, in all its forms whether natural or processed (corn syrup, agave syrup, honey, cane sugar, high-fructose corn syrup, etc.) promotes not only inflammation, a depressed immune system, but damage to the skin and to our internal tissues or organs as well. This is the result of a chemical reaction in the body called glycation. The majority of people have an excess sugar intake, and excess sugars initiate glycation at an increased rate.

The human body depends on sugar and oxygen to provide the energy.

The mitochondria power up every cell in our body using glucose, fatty acids, and oxygen. 

But it comes with a price…

When you cut an apple and wait, what happens? 

That brown color begins to appear….. a result of oxidation.  We’ve all seen the crispy browned potatoes, a roast chicken, toast, the charred grilled steak or the crispy fried chicken, that crispiness is glycation or caramelization (browning).  

When proteins and sugars attach, glycation occurs, and this same process happens to the tissue in the human body as well – the caramelization of our bodily tissues.  Eating foods with high sugar content or that have been processed with high heat (like deep-frying) means you’re ingesting another form of glycation – Advanced Glycation End Products or AGEs (as is so aptly named) directly. 

Think of your cells as engines running on fuel, with much exhaust. Well-tuned engines run clean. When our cells are operating healthfully, they burn energy efficiently  Not-so-well-tuned engines produce thick, black smoke. 
Similarly, unhealthy cells operating inefficiently produce more exhaust and acid. Toxic residue then begins to accumulate in and around the harmful cells. This degrades our cellular health and the engines that run our cells; our mitochondria. Our mitochondria are key to our optimal health. Sugar is the most damaging compound to mitochondria.

As glycation progresses, this leads to mitochondrial energy production that slows down, along with increased oxidative stress. Eventually, damaged mitochondria can stop functioning, accelerating the aging process both inside and outside the body.

Glycation takes its toll slowly. It gums up your proteins, deactivates your enzymes, triggers unhealthy, cellular signaling and damages your DNA = AGEing you.

The two tissues in our skin that make us look so youthful and spring are elastin and collagen. The worst part?  They are the very proteins that attach to the sugar in our body creating glycation – attacking these two proteins which become discolored, weak and hardened and eventually we see wrinkles, sagging skin and a loss of radiance.

But remember, this is not just happening with the tissues on the outside of our body….more importantly, it is also affecting the tissues on the inside of our body as well contributing to diseases such as heart disease, cataracts or cancer, and kidney health.

Glycation is a natural process in the human body because most everything that we eat converts to glucose – even veggies!  However, concentrated types of sugar ingestion speed up the process and have a more powerful, robust glycating effect.

The good news? 




Glycation can be powerfully slowed. Choosing an anti-inflammatory lifestyle 
will take you to more youthful skin and optimized health:

Avoid Added Sugar in All Forms.
Avoid Excess Carbohydrate Intake. Such as whole wheat bread, white potatoes, white rice, pasta, and all grains. Excess healthy carbs are also a contributor to glycation.

Avoid High-Temperature Cooking (think crispy, blackened foods).  Steaming, stewing and poaching are the cooking methods rather than frying, direct-fire grilling and high-temperature roasting.

Add Antioxidant Rich Foods:  Make every plate and anti-inflammatory meal.  Choose all veggies, nuts, seeds, low-sugar fruits such as raspberries, blackberries, kiwi, healthy fats such as avocados, macadamia nut oil, and healthy proteins such as whole pastured eggs,

Add Targeted Supplements to Prevent Glycation and AGEs: 


Carnosine. Carnosine helps prevent cellular glycation. This nutrient is a potent free-radical scavenger and the anti-glycating agent that inhibits AGEs formation and its cross-linked proteins. Take carnosine with fat for bio-availability. 

Benfotiamine.  This nutrient (a lipid-soluble form of thiamine, vitamin B1) can boost your body’s cellular levels of vitamin B1, which is an essential component in clearing the dangerous debris left behind due to glycation.

Curcumin. Curcumin is the active component in the spice turmeric.  Curcumin is an antioxidant, powerful anti-inflammatory, antimicrobial, anticancer, memory-enhancing, life-extending, and Curcumin uniquely protects against AGE-induced diabetic complications.

Tomato Paste.  Research shows that simple tomato paste strongly inhibited the formation of AGEs in the glycation process.

Resveratrol.  Resveratrol has the ability to reduce oxidative stress along with its highly protective cellular effect.
Rosemary. The use of the herb rosemary will help reduce the formation of AGEs.

Alpha Lipoic Acid.  Alpha Lipoic Acid possesses unique properties that specifically slow mitochondrial dysfunction and reversing mitochondrial damage by preventing the release of damaging oxidants.  

Taking action will prevent and improve aging skin creating healthier, more youthful skin and in general, significantly help reduce aging.

References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583887/
Thorpe SR, Baynes JW. Role of the Maillard reaction in diabetes mellitus and diseases of aging. Drugs Aging. 1996 Aug;9(2):69-77.
Li Q, Chen AH, Song XD, et al. Analysis of glucose levels and the risk for coronary heart disease in elderly patients in Guangzhou Haizhu district. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jun;30(6):1275-8.
Van Boekel MA. The role of glycation in aging and diabetes mellitus. Mol Biol Rep. 1991 May;15(2):57-64.
Sztanke K, Pasternak K. The Maillard reaction and its consequences for a living body. Ann Univ Mariae Curie Sklodowska Med. 2003;58(2):159-62.
Berrone E, Beltramo E, Solimine C, Ape AU, Porta M. Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. J Biol Chem. 2006 Apr 7;281(14):9307-13.
Kiho et al. Tomato paste fraction inhibiting the formation of advanced glycation end-products. Biosci Biotechnol Biochem 68:200-5 (2004).
Jain et al. Effect of curcumin on protein glycosylation, lipid peroxidation, and oxygen radical generation in human red blood cells exposed to high glucose levels. Free Rad Biol Med 41:92-6 (2006).
https://www.ncbi.nlm.nih.gov/pubmed/27596404
Liu J. The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview. Neurochem Res. 2008 Jan;33(1):194-203.